Search results for "Intrinsic immunity"
showing 3 items of 3 documents
The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation
2018
The tegument of human cytomegalovirus (HCMV) virions contains proteins that interfere with both the intrinsic and the innate immunity. One protein with a thus far unknown function is pUL25. The deletion of pUL25 in a viral mutant (Towne-ΔUL25) had no impact on the release of virions and subviral dense bodies or on virion morphogenesis. Proteomic analyses showed few alterations in the overall protein composition of extracellular particles. A surprising result, however, was the almost complete absence of pUL26 in virions and dense bodies of Towne-ΔUL25 and a reduction of the large isoform pUL26-p27 in mutant virus-infected cells. pUL26 had been shown to inhibit protein conjugation with the in…
The echinoderm innate humoral immune response
2015
Abstract: Multicellular organisms have an immune system, which is essential for the survival of living beings. Interest in the immune system has been expanded since common characteristics of innate immunity between Drosophila melanogaster (Meigen, 1830) and mammals were discovered in the 1980. Since then, immunology has mainly focused on the adaptive immune system that seems to be restricted to vertebrates. Unlike the innate immunity, the adaptive one is acquired after exposure to a specific antigen (Ag) and includes: antigen-presenting cells such as macrophages, proliferation of B and T lymphocytes, Ag-specific antibody/cytokine production and immunological memory. Innate immunity is inste…
Has innate immunity evolved through different routes?
2010
Invertebrate self/non-self recognition, defense responses, mating and development share innate immune surveillance and functions challenged by competition and linked to fitness. Independent evolutionary branches of immune responses may use conserved gene traits. On the other hand immunity genes may be conserved due to their role in development. Finally, upregulation of innate immunity genes during ascidian metamorphosis supports the danger hypothesis.